Subgroup analyses of trials achieving ⩾80 nmol/l indicated a trend for lower CRP (WMD=−0.834, (−1.726, 0.058) mg/l, P=0.067), however heterogeneity was significant ( I 2=66.7%, P=0.017). Of 14 studies that met our criteria, 9 studies (15 study arms) permitted extraction of data. Selected RCTs were ⩾12 weeks, conducted in adults free of acute inflammatory disease, and of high-quality (Jadad score ⩾3). Further metabolism also occurs in the kidneys, including the formation of the 1,24,25-trihydroxy derivatives.Įxcretion: Mainly in the bile & faeces with only small amounts appearing in urine.Causal links between vitamin D status and systemic inflammation were examined through a systematic review of randomized controlled trials (RCTs). Further hydroxylated in the kidneys by the enzyme vitamin D1-hydroxylase to form the active metabolites 1,25-dihydroxycholecalciferol (calcitriol). Metabolism: Hydroxylated in the liver by the enzyme vitamin D 25-hydroxylase to form 25-hydroxycholecalciferol (calcifediol). Slowly released from storage sites & skin where it is formed in the presence of sunlight or uv light. Can be stored in adipose & muscle tissue for long periods of time.

Hence absorption may be decreased in patients with decreased fat absorption.ĭistribution: Bound to a specific α-globulin. Presence of bile is essential for adequate intestinal absorption. Along with parathyroid hormone & calcitonin, regulate serum calcium conc.ĭuration: Relatively prolonged duration of action.Ībsorption: Well absorbed from the GI tract.

Description: Vit D may have anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant & mood-modulatory activities.

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